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Lactate accumulation also induces the transition of M1-type macrophages to M2-type macrophages through the modification of histone lactylation, which acts as a lactate timer [359]

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Sun Y, Wang P, Yang W, Shan Y, Zhang Q, Wu H

Similarly, MSCs-derived exosomes obtained from patient serum lessened cartilage damage by reducing TNF- and IL-12 (113)

LDX also reduces monoamine degradation by MAO inhibition [167, 168]

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